Review 3 - Published February 2008
Formaldehyde from contaminated air, at very low concentrations(11), causes cancer in humans. Formaldehyde is a powerful cancer causing agent, one of the handful of chemicals classed as a Group I carcinogen by the IARC, the International Agency for Research on Cancer, Lyon, France(11), because of this there is no known safe level of formaldehyde exposure. Gaseous environmental formaldehyde causes nasopharyngeal cancer, however, it is not known, in the gaseous form, to cause breast cancer. The probable reason for this is that formaldehyde has an extremely high reactivity(201) it reacts with and does its damage to the first human tissue with which it makes contact. Formaldehyde does not travel well in protein rich blood supply(122) and because of this it is blocked from reaching the breast and other internal organs. The only way that formaldehyde can reach the mammary tissue, aside from purposely injecting formaldehyde solution(122) (as in embalming) is to disguise the formaldehyde as methanol. The methanol from Aspartame can reach a woman’s breast and will there is readily converted into formaldehyde by ADH(190b).
It is not possible to prevent Aspartame from producing the cancer causing compound formaldehyde in a woman’s breast(78). All of the methanol in diet soda must be transformed into formaldehyde before the body can metabolize it. The scientifically acclaimed Ramazzini Institute recently found consumption of Aspartame over time caused Breast Cancer in Rats(50). The methanol that is responsible for producing this formaldehyde is also found in our processed food supply, the average modern woman not exposed to diet products consumes, conservatively, less than 8 milligrams of it a day(1). Methanol has be implicated as a possible cause of the increase of breast cancer over the last 25 years and can be found in human milk(219). One can of diet soda contains over 4 times this amount, one liter almost 20 times what would be average. Primitive and or impoverished woman consume little methanol and are protected, to a very great extent, from breast cancer. Conversely increased consumption of Aspartame has caused breast cancer rates to increase dramatically(194).
The breast is an organ with no way to protect itself from formaldehyde(216) with no means to render it harmless. The methanol, always produced when Aspartame is consumed (20,51),will convert directly into formaldehyde, there is no intermediate compound or alternate path(7,30). “Class I Alcohol dehydrogenase” ADH is required for the conversion of methanol to formaldehyde(112). ADH is not a common enzyme in the human body, not many cells in the human body contains this enzyme. The human breast is one of the few organs in the body with a high concentration of ADH(190b) and it is found there exclusively in the mammary epithelial cells, the very cells known to transform into adenocarcinoma(190c) (breast cancer) cells with very low aldehyde dehydrogenase activity(216).
The most recent breast cancer scientific literature implicates ADH as perhaps having a pivotal role in the formation of breast cancer, indicating a greater incidence of the disease in those with higher levels of ADH activity in their breasts(190a). One article went so far as to implicate acetaldehyde as a potential culprit(190a). Acetaldehyde is the molecule that ethanol is metabolized into by ADH, the first step in the manufacture of vinegar, a beneficial molecule with no link to carcinogenicity, what so ever. Recent scientific literature is a desert when it comes to methanol. It is as if there were no such thing as methanol in the environment as if methanol did not exist, as if all the laboratories doing work in methanol toxicity had vanished from the face of the earth 40 years ago and with them the science of methanol poisoning(39).
The truth is that methanol acts as a golden bullet, wasting none of its destructive power but administering a carcinogen directly inside those breast cells most vulnerable to cancer.
All of the hundreds of test that were done to prove Aspartame safe were done on animals insensitive to methanol poisoning(78). This was well known to the company who invented Aspartame, why else would they have hired the worlds methanol research laboratories to help them prove aspartame was safe(39)? These animals have a specialized catalase enzyme in their livers that humans do not(55). Catalase helps keep methanol out of their general circulation and therefore they are mostly immune to methanol as a poison. Many thousands of people lost their lives in the early nineteen hundreds when methanol was allowed in foods and medications after it was proven falsely safe by trusting methanol safety testing done on an identical array of animals(17,30).
Twenty six years ago I traveled from my laboratory at Arizona State University to Washington DC to view the results of the testing done by the company who invented Aspartame and were seeking it’s approval for use in carbonated beverages. I will never forget viewing the data from the only high dosage human consumption study done on diabetics. This study was never to be repeated. Before the test began the subjects were screened for all manner of illnesses and certified disease free (save from diabetes) as a prerequisite to being accepted into the study. During that study, after 11 weeks of high dose aspartame consumption two of the women developed epithelial cancer. Both were removed from the study, one had a mastectomy, subsequent pathology tested conclusively for adenocarcinoma. To my most profound horror, the executive summary of that study concluded that Aspartame was safe! The rational used to ignore the fact that none of the placebo group but fully 8% of the Aspartame consumption subjects developed epithelial cancer during the high dosage consumption study was that “no such cancers were seen in the numerous animal studies”(48). The Bressler Report exposed that this was, in fact. a lie (197), These cancers should have never been ignored.
I can not say that methanol is the only cause of breast cancer, there are so many other poisons in our modern environment. I will say that it is intuitively obvious that there would be no good done producing one more cancer causing agent inside a sensitive breast cell already exposed to other cancer causing agents.
Breast cancer, as with MS may possibly be linked to cigarette smoking(191) which is a source of methanol (even though smoking would be a much more efficient mechanism to administer methanol to the brain than the breast). The uneven distribution of both MS and Breast cancer throughout the world show a disarming similarity(193) even to the unexplained increases to epidemic proportions in the same regions over the last 30 years(190), such as Japan(192). Then of course we have the chart I presented in the December issue of Fitness Life showing a disconcerting, abrupt rise in incidence of breast cancer coinciding exactly with the ramp up of Aspartame consumption after it was approved for sweetening carbonated beverages in the United States(194).
As a food scientist I have been trained to detect food borne disease. Breast cancer and MS are two diseases that I believe are linked to methanol poisoning derived primarily from food. With this observation I hope to point the way to my colleagues in the healing arts to continue with the investigation of this poisoning.
Unfortunately no major pharmacological laboratory anywhere in the world seems to have any time for studying poisoning. The considerable brain power of medical research seems mesmerized by the quest for ever more expensive cures while leaving the details of prevention to the “lesser” sciences. The reason’s for this are obvious… to cure a poisoning you need only teach how to limit exposure… there is no real money to be made from good advice.
A courageous new history may someday designate our era as the dark ages of the health sciences.
Poison taints the “swich licour” in which our tissues are “bathed”. Knowing the cause of any malfunction in our almost perfect workings we must consider first the impact of our poisoned environment.
The wild natural world of our ancient forbearers seems, to me, a friendlier place to our countenance than this one we have tamed with new processes and chemical tools who’s power we do not fully understand and appear to have no interest in knowing.
Methanol is an unwanted residue of our quest for leisure and release from the burden of constant search for sustenance(194). It has been around since man first tasted meat cooked on an open fire or was forced, by hunger, to eat a fruit long past its prime(35). It has been to our great disadvantage that it has now been made to taste sweet(14).
Here then is the bizarre, dark side to sweet Aspartame. Its workings are too rich in design and simple in nature to have been plotted, in purpose, by any human hand… to splendid to consign to serendipity. There is magic in the mischief of this little molecule. I suggest that we will be surprised to learn what it can teach us.
1. Monte WC. 1994. Aspartame; Methanol and the Public Health. Journal of Applied Nutrition. 36(1):42
2. Monte WC, Glanzman D. and Johnston CS. 1990. Methanol as a Model Etiologic Agent in Multiple Sclerosis. FASEB 74th annual meeting Feb 26;4(3):Abstract
3. Personal Communication, 2006. Bill Richardson, 1/1/2006
4. Kallen RG, Jencks WP. 1966. Equilibria for the Reaction of Amines with Formaldehyde and Protons in Aqueous Solution. J Biol Chem 241 (24): 5864
5. Henzi, H. 1980. The Methanol Hypothesis A New Concept of Multiple Sclerosis: (M Sr N), Juris Druck, Zurich (1980)
6. Schwyzer, RU. Henzi, H. 1983. Multiple Sclerosis: Plaques Caused by 2-Step Demyelination? Medical Hypothesis. 12:129
7. Trocho C., Pardo R, Fafecas I, Virgili J, Remesar X, Fernandez-Lopez, J A. Formaldehyde derived from dietary aspartame binds to tissue components in vivo. Life Sci 1988: 63: 337
8. Henzi, H. 1984. Chronic Methanol Poisoning with the Clinical and Pathologic-Anatomical Features of Multiple Sclerosis Medical Hypothesis. 13:63
9. Schwyzer, RU. Henzi, H. 1988. Reflections on the Pathogenesis of Optic (Retrobulbar) Neuritis in Multiple Sclerosis. Medical Hypothesis. 27:167
10. Schwyzer, RU. Henzi, H. 1992. Multiple Sclerosis: Prevention of Serious Illness – Vision of a Desired Future for Newly Ascertained Patients. Medical Hypothesis. 37:115
11. Rousseau M-C, Straif K. Siemiatycki J. 2005, IARC Carcinogen Update. Environmental Health Perspectives 113, (9) A580
12. Apol AG. 1981. Health Hazard Evaluation Report. PB82-19464 8. NIOSH U. S .Dept. of Health and Human Services HETA 81-177, 178,988 University of Washington Seattle, Washington
13. Center for Disease Control 1976. Occupational Exposure to Methyl Alcohol. U.S. Department of Health, Education, and Welfare HEW.NIOSH Pub No .(76-148)
14. Anonymous1984. Aspartame for use as a Sweetener in Carbonated Beverages. Searle Research and Development. Petition submitted to the United States Food and Drug Administration - FAP 2A3661
15. Eisenberg AA. 1917. Visceral Changes in Wood Alcohol Poisoning by Inhalation. American Journal of Public Health. 7:765
16. Bennett IL, Cary FH, Michell GL. and Cooper MN. 1953. Acute Methyl Alcohol Poisoning; A Review Based on Experience in an Outbreak of 323 Cases. Medicine 32:431
17. Wimer WW, Russell JA, and Kaplan HL. 1983. Alcohols Toxicology. Alcohols Toxicology, Noyes Data Corporation. 8
18. Gaul HP, Wallace CJ, Auer RN, et al. 1995. MR findings in methanol intoxication. AJNR Am J Neuroradiol 1995;16:1783
19. Francot P and Geoffroy P. 1956. Le Methanol dans les jus de fruits, les boissons, fermentees, les alcools et spiritueux. Revue Des Fermentations Et Des Industries Alimentaires. 11:279
20. Davoli F. Cappellini L. Airoldi L. Fanelli R. 1986. Serum methanol concentrations in rats and in men after a single dose of aspartame. Food Chem Toxicol. 24(3):187 21. Schneck SA. 1979. Methyl alcohol. Handbook of Clinical Neurophysiology. 36:351
22. Personal Communication
23. Horiuchi S, Takata K, and Morino Y. 1985. Scavenger Receptor for Aldehyde-modified Proteins. The Journal of Biological Chemistry. 261(11):4962
24. Horiuchi S, Takata K, and Morino Y. 1985. Purification of a Receptor for Formaldehyde-treated Serum Albumin from Rat Liver. The Journal of Biological Chemistry. 260(1):482
25. Horiuchi S, Takata K, and Morino Y. 1985. Characterization of a Membrane-associated Receptor from Rat Sinusoidal Liver Cells That Binds Formaldehyde-treated Serum Albumin. The Journal of Biological Chemistry. 260(1):475
26. Metz, B., W. Jiskoot, W.E. Hennink, D.J.A. Crommelin, and G.F.A. Kersten, Physicochemical and immunochemical techniques predict the quality of diphtheria toxoid vaccines. Vaccine, 2003. 22: 156-167
27. Streitwieser A and Heathcock CH. 1985. Introduction to Organic Chemistry. Macmillan Publishing Co. 3rd Ed.:357
28. Kirchner JG and Miller JM. 1967. Volatile Water-Soluble and Oil Constituents of Valencia Orange Juice. Agricultural and Food Chemistry. 5(4):283
29. Lund ED, Kirkland CL, and Shaw PE. 1981. Methanol, Ethanol, and Acetaldehyde Contents of Citrus Products. Agricultural and Food Chemistry. 29:361
30. Koivusalo M. 1956. Studies on the Metabolism of Methanol and Formaldehyde in the Animal Organism. Acta Physiologica Scandinavica. 39.:1
31. Buys CHCM, De Jong ASH, Bouma JMW, and Gruber M. 1975. Rapid Uptake by Liver Sinusoidal Cells of Serum Albumin Modified with Retention of its Compact Conformation. Biochimica et Biophysica Acta. 392:95
32. Buys CHCM, Elferink GL, Bouma JMW, Gruber M, and Nieuwenhuis P. 1973. Proteolysis of Formaldehyde-treated Albumin in Kupffer Cells and Its Inhibition by Suramin. Journal of the Reticuloendothelial Society. 14:209
33. Gruner O and Bilzer N. 1983. Methanol content of fruit-juices. Its significance in congener analysis. Blutalkohol. 20:241
34. Casey JC, Self R, and Swain T. 1963. Origin of Methanol and Dimethyl Sulphide from Cooked Foods. Nature. 200:885
35. Braverman JBS and Lifshitz A. 1957. Pectin Hydrolysis in Certain Fruits during Alcoholic Fermentation. Food Technology. July:356
36. Campbell LA and Palmer GH. 1994. Pectin in Topics in Dietary Fiber Research. Pectin in Topics in Dietary Fiber Research, Spiller GA and Amen RJ (eds.).Plenum Press, New York, 105
37. Fink WH. 1994. The ocular pathology of methyl-alcohol poisoning. Amer J Ophthal. 26:694,802
38. Millman RB. 1982. Alcohol; The Friendly Foe. In Science Year, The World Book Science Annual. 112
39. Gordon G. 1987. UPI Investigative Report NutraSweet Questions Swirl (How Sweet It Isn't). Seattle Times Oct.:
40. Tephly TR: 1999. Comments on the purported generation of formaldehyde from the sweetener aspartame. Life Sci 65: 157-160. [ letter, not peer-reviewed]
41. Lutton JD. Winston R. Rodman TC. 2004. Multiple Sclerosis: Etiological Mechanisms and Future Directions. Experimental Biology and Medicine 229:12-20
42. Eisenberg AA. 1917. Visceral Changes in Wood Alcohol Poisoning by Inhalation. American Journal of Public Health. 7:765
43. Alexander L, Berkeley AW, and Alexander AM. 1961. Multiple Sclerosis Prognosis and Treatment. Multiple Sclerosis Prognosis and Treatment. Charles C Thomas Publisher USA
44. Hallpike JF, Adams CWM, and Tourtellotte WW. 1983. Multiple Sclerosis. Pathology, diagnosis and management, Williams & Wilkins, Baltimore
45. History of MS, 2007 Multiple Sclerosis Trust, http://www.mstrust.org.uk/information/a2z/history.jsp
46. The History of Food Canning. http://www.westlerfoods.com/pdf/canning_process.pdf
47. Scientific Abuse in Methanol / Formaldehyde Research related to Aspartame http://www.holisticmed.com/aspartame/abuse/methanol.html
48. Anonymous1994. Aspartame for use as a Sweetener in Carbonated Beverages. Searle Research and Development. Petition submitted to the United States Food and Drug Administration - FAP 2A3661
49. Methanol Danger Sign, T&B Westline
50. Soffritti M. Belpoggi F. Esposti DD. Lambertini L. Tibaldi E. and Rigano A. 2006,Results of Long-Term Carcinogenicity Bioassay on Sprague-Dawley Rats Exposed to Aspartame Administered in Feed. Ann. N.Y. Acad. Sci. 1076: 559
51. Soffritti M. Belpoggi F. Cevolani D. Guarino M. Padovani M. and Maltoni C. 2002,Results of Long-Term Results of Long-Term Experimental Studies on the Carcinogenicity of Methyl Alcohol and Ethyl Alcohol in Rats N.Y. Acad. Sci. 982: 46
52. Roe O. 1982. Species Differences in Methanol Poisoning. I. Minimal Lethal Doses, Symptoms, and Toxic Sequelae of Methanol Poisoning in Humans and Experimental Apter 18,376,390. CRC Critical Reviews in Toxicology. 275
53. Rao KR, Aurora AL, Muthaiyan S, and Ramakrishnan S. 1977. Methanol toxicity - an experimental study. Bull. Jawaharlal Inst. Post-Grad.Med.Educ.Res. 2:1
54. Walton, R.G., R. Hudak, and R.J. Green-Waite. 1993. Adverse Reactions to Aspartame: Double-Blind Challenge in Patients from a Vulnerable Population. Biological Psychiatry 34:13
55. Smith EN and Taylor RT. 1982. Acute Toxicity of Methanol in the Folate-Deficient Acatalasemic Mouse. Toxicology 25:271
56. Thomas P. 2005 Aspartame: The Shocking Story of the World’s Bestselling Sweetener. The Ecologist Sept. 36
57. Department of Health and Human Services U.S. FDA. 1979 Decision of the Public Board of Inquiry (Docket No. 75F-0355). 44 Fed. Reg. 31716
58. Center for Disease Control 1984. Evaluation of Consumer Complaints Related to Aspartame Use. Morbidity and Mortality Weekly Report. 33:605
59. Center for Disease Control 1976. Occupational Exposure to Methyl Alcohol. U.S. Department of Health, Education, and Welfare HEW.NIOSH Pub No .(76-148)
60. Office of Hon Pete Hodgson, NZ Minister of Health. 2007, Personal Communication;
61. Frankenburg WG. 1950. Chemical Changes in the Harvested Tobacco Leaf. Part II. Chemical and Enzymic Conversions during Fermentation and Aging. Advances in Enzymology. 10:351
62. Neuberg C. Kobel M. 1939. Uber die encymatische Abspaltung von Methylalkohol aus Pektin durch ein Ferment dis Tabaks. Zeitschrift für Lebensmitteluntersuchung und -Forschung A 77:3 272
63. Newsome JR, Normal V, and Keith CH. 1965. Vapor Phase Analysis of Cigarette Smoke. Tobacco Science 9:102
64. Larsson BT. 1965. Gas Chromatography of Organic Volatiles in Human Breath and Saliva. Acta Chemica Scandinavica. 19:159
65. Fellenberg T von. 1918. Uber den Nachweis und die Bestimmung des Methylalkohols, sein Vorkommen in den verschiedenen Nahrungsmitteln und das Verhalten der methylalkoholhaltland. Biochem Z. 85:45
66. Kertesz ZI. 1951. The Pectic Substances. The Pectic Substances. New York; Interscience Publishers Inc.
67. Hernan MA. Olek MJ. Ascherio A. 2001 Cigarette Smoking and Incidence of Multiple Sclerosis. American Journal of Epidemiology 154:69-74
68. Miguel AH. Jick SS. Logroscino G. Olek MJ. Ascherio A. and Jick H. Cigarette smoking and the progression of multiple sclerosis. Brain 2005 128(6):1461-1465
69. Barclay L. Lie D. Smoking May Transform Relapsing-Remitting MS Into Secondary Progressive MS. Brain. Posted online March 9, 2005. www.medscape.com/viewarticle/503872?rss
70. Hernán MA, Jick SS, Logroscino G, Olek MJ, Ascherio A, Jick H. 2005 Cigarette smoking and the progression of multiple sclerosis. Brain. 128(Pt 6):1461-5. Epub 2005 Mar 9
70a. Brey RL. 2003 Cigarette smoking and MS: Yet another reason to quit. Neurology. Oct 28;61(8):E11-2
70b. Costenbader KH, Karlson EW. Cigarette smoking and autoimmune disease: what can we learn from epidemiology? Lupus. 2006;15(11):737-45
70c. Riise T, Nortvedt MW, Ascherio A. Smoking is a risk factor for multiple sclerosis. Neurology. 2003 Oct 28;61(8):1122-4
70d. Hernán MA. Olek MJ. Ascherio A. 2001 Cigarette smoking and Incidence of Multiple Sclerosis. American Journal of Epidemiology. 154(1):69-74
71. Nortvedt MW. Riise T. Maeland JG. 2005 Multiple sclerosis and lifestyle factors: The Hordaland Health Study. Neurol Sci 26:334-339
72. Bamford RB. Sibley WA. And Thies C. 1983 Seasonal variation of multiple sclerosis exacerbations in Arizona. Neurology 33;697-701
72a. Ogawa G. Mochizuki H. Kanzaki M. Kaida K. Motoyoshi K. Kamakura K. 2003 Seasonal variation of multiple sclerosis exacerbations in Japan. Neurol Sci 24;417-419
72b. Abella-Corral J. Prieto JM. Dapena-Bolaño D. Iglesias-Gómez S. Noya-García M. Lema M. 2005 (Seasonal variations in the outbreaks in patients with multiple sclerosis) Rev Neurol 40(7):394-396
73. Hardy CJ. Palmer BP. Muir KR. Sutton AJ. Powell RJ. 1998 Smoking history, alcohol consumption, and systemic lupus erythematosus: a case-control study Ann Rheum Dis 57:451-455
74. Landtblom A-M. Flodin U. Sodeifeldt B. Wolfson C. Axelson O. 1996, Organic Solvents and Multiple Sclerosis: A Synthesis of the Current Evidence Epidemiology Vol.7 # 4 429-433
75. Grabenstein JD. 2006 Excipient content of U.S. Vaccines ImmunoFacts: Vaccines & Immunologic Drugs. St. Louis, MO: Wolters Kluwer Health Inc.
76. Weiner HL. Dau PC. Khatri BO. Petajan JH. Birnbaum G. McQuillen MP. Fosburg MT. Feldstein M. Orav EJ. 1989 Double-blind study of true vs. sham plasma exchange in patients treated with immunosuppression for acute attacks of multiple sclerosis. Neurology. 39(9):1143-9
77. Hirtz D. Thurman DJ. Gwinn-Hardy K. Mohamed M. Chaudhuri AR. Zalutsky R. 2007 How common are the "common" neurologic disorders? . Neurology. 68:326-337
78. Monte WC. 2007 Sickly Sweet: Is your Diet Sweetener Killing You? Fitness Life 33: 30-33
79. Corona T. Roman GC. 2005 Multiple Sclerosis in Latin America. Neuroepidemiology 26: 1-3
79a. Celius EG. Vandvik B. 2001 Multiple sclerosis in Oslo, Norway: prevalence on 1 January 1995 and incidence over a 25-year period. European Journal of Neurology 8:(5) 463
79b. Barnett MH. Williams DB. Day S Macaskill P. McLeod JG. 2003 Progressive increase in incidence and prevalence of multiple sclerosis in Newcastle, Australia: a 35-year study. J Neurol Sci. 15;213(1-2):1-6.
79c. Sumelahti ML, Tienari PJ, Wikström J, Palo J, Hakama M. 2001 Increasing prevalence of multiple sclerosis in Finland Acta Neurol Scand. 103(3):153-8
79d. Pugliatti M. Sotgiu S. Solinas G. Castiglia P. Pirastru MI. Murgia B. Mannu L. Sanna G. Rosati G. 2001 Multiple sclerosis epidemiology in Sardinia: evidence for a true increasing risk. Acta Neurol Scand. 103(1):20-6
79e. Sundström P. Nyström L. Forsgren L. 2003 Incidence (1988-97) and prevalence (1997) of multiple sclerosis in Västerbotten County in northern Sweden. J Neurol Neurosurg Psychiatry. 74(1):29-32
79f. Pugliatti M. Riise T. Sotgiu MA. Sotgiu S. Satta WM. Mannu L. Sanna G. Rosati G. 2005 Increasing incidence of multiple sclerosis in the province of Sassari, northern Sardinia. Neuroepidemiology 25(3):129-34. Epub 2005 Jun 29.
79g. Pozzilli C. Romano S. Cannoni S. 2002 Epidemiology and current treatment of multiple sclerosis in Europe today. J Rehabil Res Dev. 39(2):175-85
79h. Pugliatti M. Sotgiu S. Rosati G. 2002 The worldwide prevalence of multiple sclerosis. Clin Neurol Neurosurg. 104(3):182-91.
79i. Gallagher L, Lea R. 2005 The epidemiology of multiple sclerosis in New Zealand. N Z Med J. 118(1212):U1396.
79j. Ranzato F, Perini P, Tzintzeva E, Tiberio M, et. al. 2003 Increasing frequency of multiple sclerosis in Padova, Italy: a 30 year epidemiological survey. Mult Scler. 9(4):387-92.
80. Grimaldi LM. Palmeri B. Salemi G. Giglia G. D'Amelio M. Grimaldi R. Vitello G. Ragonese P. Savettieri G. 2007 High prevalence and fast rising incidence of multiple sclerosis in Caltanissetta, Sicily, southern Italy. Neuroepidemiology. 28(1):28-32. Epub 2006 Dec 8.
80a. Barnett MH. Williams DB. Day S Macaskill P. McLeod JG. 2003 Progressive increase in incidence and prevalence of multiple sclerosis in Newcastle, Australia: a 35-year study. J Neurol Sci. 15;213(1-2):1-6.
80b. Granieri E. Casetta I. Govoni V. Tola MR. Marchi D. Murgia SB. Ticca A. Pugliatti M. Murgia B. Rosati G. 2000 The increasing incidence and prevalence of MS in a Sardinian province. Neurology 26;55(6):842-8
80c. Grimaldi LM. Salemi G. Grimaldi G. Rizzo A. Marziolo R. Lo Presti C. Maimone D. Savettieri G. 2001 High incidence and increasing prevalence of MS in Enna (Sicily), southern Italy. Neurology 57(10):1891-3
81. Kira J. 2006 Epidemiology of multiple sclerosis in Japanese: with special reference to opticopsinal multiple sclerosis. Rinsho Shinkeigaku. 46(11):859-62
81a. Tanaka K, Kujuro Y, Suzuki S, Tanahashi N, Hamada J, Nogawa S, Suzuki N. Clinical and laboratory features of in-patients with multiple sclerosis in a University Hospital in Tokyo from 1988-2002. Intern Med. 2005 Jun;44(6):560-6
82. Access Economics, 2005 Acting Positively: Strategic Implications of the Economic costs of Multiple Sclerosis in Australia www.ms.org.au/msinformation/articles/MSFINALREPORTWINTER2005.pdf
83. Lazoff M. 2005 Multiple Sclerosis Symptoms. eMedicin WebMD www.emedicine.com/emerg/topic321.htm#section%7Eauthor_information
84. Waksman B. 1985 Mechanisms in multiple sclerosis. Nature 318: 104
85. Leibowitz U and Alter M. 1973. Multiple Sclerosis: Clues to its cause. North-Holland Publishing Co.
86. Kieseier B. Hemmer B. Hartung HP. 2005 Multiple Sclerosis –novel insights and new therapeutic strategies. Current Opinion in Neurology 18:211- 220
87. Ibrahim SM. Gold R. 2005 Genomics, promeomics, metabolomics: what is in a word for multiple sclerosis. Current Opinion in Neurology 18:231 – 235
88. Wikipedia, the free encyclopedia. 2007 Glial cell. http://en.wikipedia.org/wiki/Glial_cell
89. National Toxicology Program, U.S. Department of Health and Human Services. 2001 NTP-CERHR Expert Panel Report on Reproductive and Developmental Toxicity of Methanol, Draft 7/17/01
90. Gallegher L. Lea R. 2005 The epidemiology of multiple sclerosis in New Zealand. The New Zealand Medical Journal 118: 1212
91. Boyles S. 2007 MS Increasingly a Woman’s Disease. MedicineNet.com www.medicinenet.com/script/main/art.asp?articlekey=80722
91a. Cutter G. et. al. 2007 Changes in the Sex Ratio over Time in Multiple Sclerosis. 59th Annual Meeting of the American Academy of Neurology, Boston April 28 – May 5, 2007
91b. Hernán MA. Olek MJ. Ascherio A. 1999 Geographic variation of MS incidence in two prospective studies of US women. Neurology 53(8):1711-8
91c. Noonan CW, Kathman SJ, White MC. 2002 Prevalence estimates for MS in the United States and evidence of an increasing trend for women. Neurology 58(1):136-8
92. Health Effects Institute 1999 Reproductive and offspring Developmental Effects Following Maternal Inhalation Exposure to Methanol in Nonhuman Primates. Research Report Number 89
93. Anonymous1984. Evaluation of Consumer Complaints Related to Aspartame Use. Morbidity and Mortality Weekly Report. 33:605
94. Frezza M, di Padova C, Pozzato G, Terpin M, Baraona E, Lieber CS. 1990 High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism. N Engl J Med. 322(2):95-9
95. Pugliatti M, Sotgiu S, Solinas G, Castiglia P, Rosati G. 2001 Multiple sclerosis prevalence among Sardinians : further evidence against the latitude gradient theory Neurol Sci. 2001 Apr;22(2):163-5
95a. Rosati G. 2001 The prevalence of multiple sclerosis in the world: an update Neurol Sci 22:117-139
96. Mahalik MP and Gautieri RF. 1984. Reflex Responsiveness of CF-1 Mouse Neonates Following Maternal Aspartame Exposure. Res Commun in Psych. 9:385
97. National Toxicology Program, U.S. Department of Health and Human Services. 2002 NTP-CERHR Expert Panel Report on Reproductive and Developmental Toxicity of Methanol NTP-CERHR-MeOH-02
98. FightingAutism.org Number of Cases http://www.fightingautism.org/idea/autism.php?
99. Gettler AO. St.George AV. 1918. Wood Alcohol Poisoning. Journal of the American Medical Association. 70:145.
100. Sturtevant FM. 1985. Use of Aspartame in Pregnancy. Int J Fertil. 30(1):85
101. Anonymous1982. Therapeutic claims in multiple sclerosis. National Multiple Sclerosis Society. National Multiple Sclerosis Society. Jan.:49
102. Sturtevant FM. 1985. Does Aspartame Cause Methanol Toxicity? Fd Chem Toxic. 23(10):961
103. Infurna R. Weiss B. 1986 Neonatal Behavioral Toxicity in Rats Following Prenatal Exposure to Methanol Teratology 33:259-265
103a. Infurna R, Schubin W, and Weiss B. 1981. Developmental Toxicology of Methanol. Toxicologist 1:32
104. Bolon B, Dorman DC, Janszen D, Morgan KT, Welsch F. 1993 Phase-specific developmental toxicity in mice following maternal methanol inhalation. Fundam Appl Toxicol. 21(4):508-16
105. Dorman DC, Bolon B, Struve MF, LaPerle KM, Wong BA, Elswick B, Welsch F. 2005 Role of formate in methanol-induced exencephaly in CD-1 mice. Teratology. 52(1):30-40
106. Potts AM, Praglin J, Farkas J, Orbison L, and Chickering D. 1976. Studies on the Visual Toxicity of Methanol. VIII. Additional Observations on Methanol Poisoning in the Primate Test Object. Amer J Ophthal. 40:76
107. Kavet R and Nauss KM. 1990. The Toxicity of Inhaled Methanol Vapors. Critical Reviews in Toxicology. 21:21
108. Rabinovitch and MD IM. 1922. Biochemical Studies in a Fatal Case of Methyl Alcohol poisoning. Archives of Internal Medicine, Chicago. 29:821
109. Kane RL, Talbert W, Harlan J, Sizemore G, and Cataland S. 1968. A methanol poisoning outbreak in Kentucky. A clinical epidemiological study. Arch Environm Hlth. 17:119
110. Menne FR. 1935. Acute Methyl Alcohol Poisoning, a Report of Twenty-Two Instances with Postmortem Examinations. Archives of Pathology. 26:77
111. Bennett IL, Cary FH, Michell GL. and Cooper MN. 1953. Acute Methyl Alcohol Poisoning; A Review Based on Experience in an Outbreak of 323 Cases. Medicine 32:431
112. Kini MM and Cooper JR. 1961. Biochemistry of Methanol Poisoning-III; The Enzymic Pathway for the Conversion of Methanol to Formaldehyde. Biochemical Pharmacology. 8:207
113. Kini MM and Cooper JR. 1962. Biochemistry of Methanol Poisoning; The Effect of Methanol and its Metabolites on Retinal Metabolism. Biochemical Journal. 82:164
114. French D and Edsall JT. 1945. The Reactions of Formaldehyde with Amino Acids and Proteins. Adv.Protein Chem 2:277
115. Leaf G and Zatman LJ. 1952. A Study of the Conditions Under Which Methanol May Exert a Toxic Hazard in Industry. British Journal of Industrial Medicine. 9:19
116. Cooper JR and Kini MM. 1962. Biochemical Aspects of methanol Poisoning. Biochemical Pharmacology. 11:405
117. Cooper JR and Felig P. 1961. The Biochemistry of Methanol Poisoning. II. Metabolic Acidosis in the Monkey. Toxicol.Appl.Pharmacol. 3:202
118. Clay KL, Murphy RC, and Watkins WD. 1975. Experimental Methanol Toxicity in the Primate; Analysis of Metabolic Acidosis. Toxicol.Appl.Pharmacol. 34:49
119. McLean DR, Jacobs H, and Mielke BW. 1979. Methanol Poisoning A Clinical and Pathological Study. Annals of Neurology 8:161
120. Posner HS. 1975. Biohazards of Methanol in Proposed New Uses. J.Toxicol.Environ.Health 1:153
121. Stegink LD. Filer LJ Tephly TR. Aspartame – The Book, Marcel Dekker, Inc New York
122. von Oettingen WF. 1943. The Aliphatic Alcohols Their Toxicity and Potential Dangers in Relation to Their Chemical Constitution and Their Fate in Metabolism. Public Health Bulletin 281:1
123. Siragusa RJ, Cerda JJ, Baig MM, Burgin CW, and Robbins FL. 1988. Methanol production from the degradation of pectin by human colonic bacteria. American Journal of Clinical Nutrition. 47:848
124. Nelson BK, Brightwell WS, MacKenzie DR, Khan A, Burg JR, Weigel WW, and Goad P. 1985. Teratological Assessment of Methanol and Ethanol at High Inhalation Levels in Rats. Fundam Appl Toxicol. 5:727
125. Sollmann T. 1920. Studies of chronic intoxications on albino rats. II. Alcohol; Methyl, ethyl, "wood" and acetone. J Pharmacol Exper Therap. 16:291
126. Victor M. 1977. Some Observations on the Neurological Effects of Alcohol Intoxication and Withdrawal. Neurotoxicology Raven Press, New York 517
127. Smith SR, Smith SJM, and Buckley BM. 1981. Combined Formate and Lactate Acidosis in Methanol Poisoning. The Lancet. 1:1295
128. Fulop, M. 1982. Methanol Intoxication. The Lancet Feb.:338
129. Roe, O. 1948. The Ganglion Cells of the Retina in Cases of Methanol Poisoning in Human Beings and Experimental Animals. Acta Opthalmologica 26:169
130. Potts AM. 1984. The Aliphatic Alcohols. Handbook of Experimental Pharmacology. 69(Pharm. Eye):639
131. Martin-Amat G, McMartin KE, Hayreh SS, Hayreh MS, and Tephly TR. 1978. Methanol Poisoning Ocular Toxicity Produced by Formate. Toxicology and Applied Pharmacology. 45:201
132. Makar AB, Tephly TR, and Mannering GJ. 1968. Methanol Metabolism in the Monkey. Molecular Pharmacology. 4:471
133. Majchrowicz E. 1973. Biochemical Pharmacology of Ethanol. Biochemical Pharmacology of Ethanol. Plenum Press, New York 122
134. Majchrowicz E and Mendelson JH. 1971. Blood Methanol Concentrations During Experimentally Induced Ethanol Intoxication in Alcoholics. The Journal of Pharmacology and Experimental Therapeutics. 179:293
135. Magrinat G, Dolan JP, Biddy RL, Miller LD, and Korol B. 1973. Ethanol and Methanol Metabolites in Alcohol Withdrawal. Nature. 244:234
136. Walder AI, Redding JS, Faillace L, and Steenberg W. 1969. Rapid Detoxification of the Acute Alcoholic with Hemodialysis. Surgery. 66:201
137. Guggenheim MA, Couch JR, and Weinberg W. 1971. Motor Dysfunction as a Permanent Complication of Methanol Ingestion. Archives of Neurology. 24:550
138. Scott E, Helz MK, and McCord CP. 1933. The Histopathology of Methyl Alcohol Poisoning. American Journal of Clinical Pathology. 3:311
139. Keyvan-Larijarni H and Tannenberg AM. 1974. Methanol Intoxication; Comparison of Peritoneal Dialysis and Hemodialysis Treatment. Arch Intern Med 134:293
140. Gronning M. Albrektsen G. Kvale G. Moen B. Aarli JA. Nyland H. 1993 Organic solvents and multiple sclerosis: a case-control study. Acta Neurol Scand 88: 247-250
141. Agner K, Hook O, and von Porat B. 1949. The Treatment of Methanol Poisoning with Ethanol. With Report of Two Cases. Quarterly Journal of Studies on Alcohol. 9:515
142. Roe O. 1950. The roles of Alkaline salts and Ethyl Alcohol in the treatment of Methanol Poisoning (1164). Quart.J.Stud.Alcohol. 11:107
143. Erlanson P, Fritz H, Hagstam K-E, Liljenberg B, Tryding N, and Voigt G. 1965. Severe Methanol Intoxication. Acta Medica Scandinavica. 177(4):393
144. Browning E. 1965. Methanol Toxicology. In Toxicity and Metabolism of Industrial Solvents. Elsevier Publishing Company, New York 315-323
145. Humphries P. Pretorius E. Naud H. 2007 Direct and indirect cellular effects of aspartame on the brain. Eur J Clin Nutr. Aug 8; 1-12
146. Isaacs R. 1920. Acute Methyl Alcohol Poisoning. J.Am.Med.Assoc.or JAMA 75:718
147. Pick L and Bielschowsky M. 1912. Ueber histologische Befunde im Auge and im Zentralnervensystem des Menschen bei akuter todlicher Vergiftung mit Methylalkohol. Klin Wschr. 49:888
148. Sharpe JA, Hostovsky M, Bilbao JM, and Rewcastle NB. 1982. Methanol optic neuropathy; A histopathological study. Neurology (Ny) 32:1093
149. Waksman BH and Reynolds WE. 1984. Multiple Sclerosis as a Disease of Immune Regulation (41798). Proceedings of the Society for Experimental Biology and Medicine 175:282
150. Pohl J. 1893. Ueber die Oxydation des Methyl Und Aethylalkohols im Thierkorper. Naunyn-Schmiedeberg's Arch exp Path Pharmak. 31:281
151. Anderson CA, Rubinstein D, Filley CM, Stears JC. 1997 MR enhancing brain lesions in methanol intoxication. J Comput Assist Tomogr. 1997 Sep-Oct;21(5):834-6
152. Fackelmann KA. 1990. Myelin on the Mend: Can antibodies reverse the ravages of multiple sclerosis?. Science News. 137:218
153. Wolfgang F. 1979. What if Multiple Sclerosis isn’t an Immunological or Viral Disease? The Case for a Circulating Toxin. Neurochemical Research 4:1-14
154. Adams CWM. 1981. Histochemical Contributions to the Study of Multiple Sclerosis. Histochemistry The Widening Horizons. Edited by P.J. Stoward and J. M. Polak 163
155. Alexander L, Berkeley AW, and Alexander AM. 1961. Multiple Sclerosis Prognosis and Treatment. Multiple Sclerosis Prognosis and Treatment. Charles C Thomas Publisher USA
156. Brown MS and Goldstein JL. 1983. Lipoprotein Metabolism in the Macrophage; Implications for Cholesterol Deposition in Atherosclerosis. Annu Rev Biochem. 52:223
157. Tephly TR. 1977. Factors in Responses to the Environment. Introduction. Federation Proceedings. 36(5):1627
158. Blundell JE and Hill AJ. 1986. Paradoxical Effects of an Intense Sweetener (Aspartame) on Appetite. Lancet May:1092
159. Coulombe RA Jr. and Sharma RP. 1986. Neurobiochemical Alterations Induced by the Artificial Sweetener Aspartame (NutraSweet). Toxicology and Applied Pharmacology. 83:79
160. Walton RG (1128). 1986. Seizure and Mania After High Intake of Aspartame. Journal of the Academy of Psychosomatis Medicine, Apr.:218
161. Roak-Foltz R and I. Leveille GA.Marcel Dekker. 1984. Projected Aspartame Intake: Daily Ingestion of Aspartic Acid, Phenylalanine, and Methanol Aspartame – The Book, Marcel Dekker, Inc New York 201
162. Main, R.H. 1903. On The Toxicity of Methyl Alcohol in Extracts and Medicine. Illinois Medical Journal 153
163. Koller, C. 1905. Poisoning by Wood Alcohol: A case of Complete Blindness (Transitory) with Recovery of Vision. Medical Record 1vxiii:10
164. Medical Record 1905 Excerpts from Doctors Letters
165. Wood, C.A. 1906. Death and Blindness as a Result of Poisoning by Methyl Alcohol or Wood Alcohol and Its Various Preparations. International Clinics; A Quarterly of Clinical Lectures 16:68
166. Kritchevsky M. 1988. Multiple Sclerosis. In Wiederholt WC, Ed.Neurology for Non-Neurologists.Philadelphia, Harcourt
167. Blaivas JG. 1984. Evaluation of Urinary Bladder Symptoms in Multiple Sclerosis. The Diagnosis of Multiple Sclerosis. Ed. Poser CM.Thieme-Stratton Inc. 76
168. Kurtzke JF. 1980. Epidemiologic contributions to multiple sclerosis; An overview. Neurology. Neurology 30(7):61
169. Matthews B. 1978. Multiple sclerosis The Facts. Multiple sclerosis The Facts. Oxford University Press
170. Mawdsley C and Mayer RF. 1965. Nerve Conduction in Alcoholic Polyneuropathy. Brain 88:335
171. Benton CD and Calhoun FP. 1952. The Ocular Effects of Methyl Alcohol Poisoning. Report of a Catastrophe involving Three Hundred and Twenty Persons. Trans Amer Acad Ophthal Otolaryng. 56:875
172. Yano K, Rhoads GG, and Kagan A. 1977. Coffee, Alcohol and Risk of Coronary Heart Disease Among Japanese Men Living in Hawaii. New England Journal of Medicine. 297:405
173. Lester D. 1961. Endogenous Ethanol; A Review. Quarterly Journal of Studies on Alcohol. 22:555
174. Lester D. 1962. The Concentration of Apparent Endogenous Ethanol. Q. J. Stud. Alcohol 23:17
175. Lieber CS and DeCarli LM. 1970. Hepatic Microsomal Ethanol-Oxidizing System. In vitro characteristics and adaptive properties in vivo. The Journal of Biological Chemistry. 245:2505
176. Klatsky AL, Friedman GD, and Siegelaub AB. 1981. Alcohol and Mortality. Annals of Internal Medicine. 95:139
177. Hoque M, Monte WC, and Johnston CS. 1988. Methanol Neuropathy A Histological Study on Long-Evans Rats. FASEB J 25;2(6):A513
178. Benditt EP. 1994. The Origin of Atherosclerosis. Scientific American. 236:74
179. Metz, B. GFA Kersten GFA. Jong A. Meiring H. 2005 Identification of formaldehyde-induced modifications in proteins: reactions with diphtheria toxin http://igitur-archive.library.uu.nl/dissertations/2005-0303-105230/c7.pdf
180. Gombos K. et.al. 2007 The effect of aspartame administration on oncogene and suppressor gene expressions. In Vivo 21(1): 89-92
181. Grey DM. 1995 Summary of Adverse Reactions Attributed to Aspartame. US Department of Health and Human Services. Personal Communication
182. Humphries P. Pretorius E. and Naude H. 2007 Direct and indirect cellular effects of aspartame on the Brain. European Journal of Clinical Nutrition 2007:1-12
183. Parthasarathy NJ. Kumar RS. Manikandan S. Devi RS 2006 Methanol-Induced Oxidative Stress in Rat Lymphoid Organs. J. Occup Health 48:20-27
184. Hawkes CW. 2002 Is multiple sclerosis a sexually transmitted infection. J Neurol Neurosurg Psychiatry. 73(4):439-43.
185. Kantarci O. Wingerchuk D. 2006 Epidemiology and natural history of multiple sclerosis: new insights. Curr Opin Neurol 19:248-254
186. Dahshan A. Donovan K. 2001 Auto-Brewery Syndrome in a Child With Short Gut Syndrome: Case Report and Review of the Literature. Journal of Pediatric Gastroenterology and Nutrition 33:214–215
187. Borras E. et. al. 2000. Genetic Polymorphism of Alcohol Dehydrogenase in Europeans: The ADH2*2 Allele Decreases the Risk for Alcoholism and Is Associated With ADH3*1. HEPATOLOGY Vol. 31, No. 4
188. Erickson SP. Kulkarni AB. 1963. Methanol in Normal Human Breath. Science 141:639
189. Wood CA and Buller F. 1904. Poisoning by Wood Alcohol. JAMA 43:972,1058,1117,1213,1.
190. Kingsbury K. 2007. The Changing Face Of Breast Cancer. TIME Magazine October 15th, 2007:36
190a. Coutelle C. et al. 2004. Risk Factors in Alcohol Associated Breast Cancer: Alcohol Dehydrogenase Polymorphism and Estrogens. International Journal of Oncology 25:1127-1132
190b. Triano E. A. et al. 2003. Class I Alcohol Dehydrogenase Is Highly Expressed in Normal Human Mammary Epithelium but not in Invasive Breast Cancer: Implications for Breast Carcinogenesis. Cancer Research Arch 63:3092-3100
190c. Poschl G. and Seitz H. K. 2004. Alcohol and Cancer (Review). Alcohol & Alcoholism 39;3:155-165
191. Gram IT. et al. 2005. Breast Cancer Risk Among Women Who Start Smoking as Teenagers. Cancer Epidemiology, Biomarkers & Prevention 14(1):61-66
192. Nagata C. et al. 2006. Tobacco Smoking and Breast Cancer Risk: An Evaluation Based on a Systematic Review of Epidemiological Evidence among the Japanese Population. Jpn J Clin Oncol 36(6):387-394
193. Kingsbury K. 2007. The Changing Face Of Breast Cancer. TIME Magazine October 15th, 2007:36
194. Monte WC. 2007 A Deadly Experiment: MS & Aspartame Are They Linked? Fitness Life 34: 36-43
195. Kurtzke JF. 2003. Epidemiology and multiple sclerosis a personal review http://www.direct-ms.org/pdf/EpidemiologyMS/EpidemiologyMS.pdf
196. Godish, T. 1989. Formaldehyde Exposures from Tobacco Smoke: A Review. American Journal of Public Health 79: #8, 1044-1045
197. Bressler J. 1977. The Bressler Report. United States Food and Drug Administration EIR JSA/DME/JT/LF 4/25/77 to 8/4/77
198. Puchtler H. Meloan SN. 1985. On the chemistry of formaldehyde fixation and its effect on immunohistochemical reactions. Histochemistry 82: 201-204
199. Taskinen HK. et al 1999. Reduced Fertility Among Female Wood Workers Exposed to Formaldehyde. American Journal of Industrial Medicine 36: 206-212
200. Metz B. et al 2004. Identification of Formaldehyde-induced Modifications in Proteins. The Journal of Biological Chemistry 279: #8 6235-6243
201. Hansen JM. Contreras KM. Harris C. 2004. Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity. Birth Defects Research (Part A) 73:72-82
202. Monte WC. Bittersweet: Aspartame Breast Cancer Link. Fitness Life 2008 Feb. 34: 21-22